- Sandwich Shop Restaurants, Portsmouth
- Satellite Descrambling & Programming Service, Portsmouth
- Satellite Dish Antennas & Equipment Dealers, Portsmouth
- Satellite TV Service, Portsmouth
- Scientific Equipment & Services, Portsmouth
- Scientific Equipment & Supplies, Portsmouth
- Scientific Services, Portsmouth
- Seals, Portsmouth - Hermetic, Hydraulic, Mechanical, Metal, Oil, Grease, etc
- Secondary Schools, Portsmouth
- Security Brokers & Dealers, Portsmouth
- Senior Citizens Service & Health Organizations, Portsmouth
- Septic Tank Installation & Repair, Portsmouth - Septic Systems
- Septic Tank Pumping & Cleaning, Portsmouth - Septic Systems
- Septic Tanks & Septic Systems Contractors, Portsmouth - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Portsmouth - Wholesale, Dealers & Suppliers
- Septic Tanks & Systems Contractors & Designers, Portsmouth
- Septic Tanks & Systems Inspection, Portsmouth
- Service Establishment Supplies & Equipment, Portsmouth
- Sewer Construction Contractors, Portsmouth - Sewer Line, Pipe Installation & Repair Services
- Sewing & Yarn Stores & Supplies, Portsmouth
- Sewing Ribbons, Portsmouth
- Ship & Boat Building & Repairing, Portsmouth
- Shoe Repair Shops, Portsmouth
- Shoe Stores, Portsmouth - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Portsmouth
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- Sign Lettering & Painting Services, Portsmouth
- Signs, Portsmouth
- Skin Care & Cosmetology Salons, Portsmouth
- Skin Care Products & Treatments, Portsmouth
- Snacks & Desserts, Portsmouth
- Social Clubs & Organizations, Portsmouth
- Social Services & Welfare, Portsmouth
- Social Workers & Services, Portsmouth
- Societies & Foundation Associations, Portsmouth
- Soda Fountain Shops, Portsmouth
- Special Events & Party Supply Rental, Portsmouth
- Special Interest Schools Or Instruction, Portsmouth
- Specialty Animal Services, Portsmouth
- Specialty Stores, Portsmouth
- Spiritualists, Portsmouth
- Sporting Goods Equipment Rental, Portsmouth
- Sporting Goods Stores, Portsmouth
- Sportswear Clothing Stores, Portsmouth - Sports Clothes
- Sprinkler Alarm Systems, Portsmouth - Fire Sprinkler Systems
- Staffing & Support Services, Portsmouth
- Stock & Bond Brokers & Dealers, Portsmouth
- Stocks & Bond Brokers, Portsmouth
- Surveyor Services, Portsmouth - Surveying Service
- Swimming Pools Supplies, Equipment & Accessories, Portsmouth
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